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Commentary 10.1172/JCI99035

Unravelling the fate of functional PD1+ T cells in chronic viral hepatitis

Eleanor Barnes

Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom (UK).

Address correspondence to: Eleanor Barnes, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford, OX1 3SY. Phone: 44.0.1865.281547; Email: ellie.barnes@ndm.ox.ac.uk.

Find articles by Barnes, E. in: JCI | PubMed | Google Scholar

First published January 8, 2018 - More info

Published in Volume 128, Issue 2 (February 1, 2018)
J Clin Invest. 2018;128(2):573–576. https://doi.org/10.1172/JCI99035.
Copyright © 2018, American Society for Clinical Investigation

First published January 8, 2018

See the related article at Hepatitis B virus–specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation.

Hepatitis B virus (HBV) infection can be managed clinically with nucleos(t)ide therapy, which suppresses viral replication; however, these drugs must often be used long term, as they are unable to fully eliminate the virus. For many patients, discontinuation of treatment results in viral resurgence and hepatic flare, and there is not a reliable way to identify those individuals that can be successfully taken off nucleos(t)ide therapy. In this issue of the JCI, Rivino and colleagues report on their use of a multipronged approach to investigate potential biomarkers indicative of HBV-infected patients who can safely stop nucleos(t)ide therapy. The authors identified a population of HBV-specific, PD1-positive T cells that was present in HBV-infected patients who successfully discontinued treatment without hepatic flare, but not in those that developed flare upon treatment cessation. Together, these results support the concept that PD1+ cells may play an important role in viral control, the further evaluation of this T cell subset in preventing hepatic flare, and the development of assays to better detect this PD1+ T cell population in HBV-infected patients on nucleos(t)ide therapy.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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