Flow-mediated vasodilation through mechanosensitive G protein-coupled receptors in endothelial cells
Y Hu, M Chen, M Wang, X Li - Trends in Cardiovascular Medicine, 2022 - Elsevier
Currently, endothelium-dependent vasodilatation involves three main mechanisms:
production of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS), synthesis of
prostanoids by cyclooxygenase, and/or opening of calcium-sensitive potassium channels.
Researchers have proposed multiple mechanosensors that may be involved in flow-
mediated vasodilation (FMD), including G protein-coupled receptors (GPCRs), ion channels,
and intercellular junction proteins, among others. However, GPCRs are considered the …
production of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS), synthesis of
prostanoids by cyclooxygenase, and/or opening of calcium-sensitive potassium channels.
Researchers have proposed multiple mechanosensors that may be involved in flow-
mediated vasodilation (FMD), including G protein-coupled receptors (GPCRs), ion channels,
and intercellular junction proteins, among others. However, GPCRs are considered the …
