[HTML][HTML] PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress
SB Cullinan, JA Diehl - Journal of Biological Chemistry, 2004 - ASBMB
The accumulation of unfolded proteins elicits a cellular response that triggers both pro-
survival and pro-apoptotic signaling events. PERK-dependent activation of NF-E2-related
factor-2 (Nrf2) is critical for survival signaling during this response; however, the mechanism
whereby Nrf2 confers a protective advantage to stressed cells remains to be defined. We
now demonstrate that Nrf2 activation contributes to the maintenance of glutathione levels,
which in turn functions as a buffer for the accumulation of reactive oxygen species during the …
survival and pro-apoptotic signaling events. PERK-dependent activation of NF-E2-related
factor-2 (Nrf2) is critical for survival signaling during this response; however, the mechanism
whereby Nrf2 confers a protective advantage to stressed cells remains to be defined. We
now demonstrate that Nrf2 activation contributes to the maintenance of glutathione levels,
which in turn functions as a buffer for the accumulation of reactive oxygen species during the …