Application of the protein synthesis inhibitor anisomycin to the rat gustatory cortex before
and during training impairs conditioned taste aversion (CTA) to saccharin. No behavioral
impairment is observed if the inhibitor is applied to an adjacent cortical area or to one
cortical hemisphere only. The consumption of saccharin and of total fluid, as well as
behavioral recognition of saccharin, is not affected. Preexposure of rats to saccharin several
days before training markedly inhibits CTA to that taste. Injection of anisomycin to the …