A genome-wide association study on African-ancestry populations for asthma
BACKGROUND: Asthma is a complex disease characterized by striking ethnic disparities
not explained entirely by environmental, social, cultural, or economic factors. Of the limited
genetic studies performed on populations of African descent, notable differences in
susceptibility allele frequencies have been observed. OBJECTIVES: We sought to test the
hypothesis that some genes might contribute to the profound disparities in asthma.
METHODS: We performed a genome-wide association study in 2 independent populations …
not explained entirely by environmental, social, cultural, or economic factors. Of the limited
genetic studies performed on populations of African descent, notable differences in
susceptibility allele frequencies have been observed. OBJECTIVES: We sought to test the
hypothesis that some genes might contribute to the profound disparities in asthma.
METHODS: We performed a genome-wide association study in 2 independent populations …