[HTML][HTML] MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4+ T-cell priming
AS McKee, DG Mack, F Crawford, AP Fontenot - Mucosal immunology, 2015 - Elsevier
Beryllium exposure results in beryllium hypersensitivity in a subset of exposed individuals,
leading to granulomatous inflammation and fibrosis in the lung. In addition to its antigenic
properties, beryllium has potent adjuvant activity that contributes to sensitization via
unknown pathways. Here we show that beryllium induces cellular death and release of
interleukin (IL)-1α and DNA into the lung. Release of IL-1α was inflammasome independent
and required for beryllium-induced neutrophil recruitment into the lung. Beryllium enhanced …
leading to granulomatous inflammation and fibrosis in the lung. In addition to its antigenic
properties, beryllium has potent adjuvant activity that contributes to sensitization via
unknown pathways. Here we show that beryllium induces cellular death and release of
interleukin (IL)-1α and DNA into the lung. Release of IL-1α was inflammasome independent
and required for beryllium-induced neutrophil recruitment into the lung. Beryllium enhanced …
