Within the domain of lipidomics, lipid mediator lipidomics and informatics is an exciting area
because of the important roles of lipid‐derived mediators in health and disease. It is well‐
appreciated that arachidonic acid is a precursor to potent bioactive mediators, such as
prostaglandins, leukotrienes, and lipoxins. Recent experiments employing a mediator‐
lipidomic approach have uncovered that other major essential polyunsaturated fatty acids,
such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), serve as …