[HTML][HTML] Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations
YR Hussein, B Weigelt, DA Levine, JK Schoolmeester… - Modern Pathology, 2015 - Elsevier
Abstract The Cancer Genome Atlas described four major genomic groups of endometrial
carcinomas, including a POLE ultramutated subtype comprising∼ 10% of endometrioid
adenocarcinoma, characterized by POLE exonuclease domain mutations, ultrahigh somatic
mutation rates, and favorable outcome. Our aim was to examine the morphological and
clinicopathological features of ultramutated endometrial carcinomas harboring somatic
POLE exonuclease domain mutations. Hematoxylin and eosin slides and pathology reports …
carcinomas, including a POLE ultramutated subtype comprising∼ 10% of endometrioid
adenocarcinoma, characterized by POLE exonuclease domain mutations, ultrahigh somatic
mutation rates, and favorable outcome. Our aim was to examine the morphological and
clinicopathological features of ultramutated endometrial carcinomas harboring somatic
POLE exonuclease domain mutations. Hematoxylin and eosin slides and pathology reports …