[HTML][HTML] Identification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent association
E Penuel, RW Akita, MX Sliwkowski - Journal of Biological Chemistry, 2002 - ASBMB
Ligand-independent ErbB2 activation occurs principally by two distinct mechanisms:
overexpression and mutation. Overexpression of ErbB2 at the plasma membrane drives
receptor self-association in a concentration-dependent manner, which in turn leads to
constitutive receptor activation. Subsets of human breast cancers contain a molecular
alteration that leads toerbB2 gene amplification and subsequent protein overexpression.
Although not recognized to occur in human cancers, mutation can also lead to increased …
overexpression and mutation. Overexpression of ErbB2 at the plasma membrane drives
receptor self-association in a concentration-dependent manner, which in turn leads to
constitutive receptor activation. Subsets of human breast cancers contain a molecular
alteration that leads toerbB2 gene amplification and subsequent protein overexpression.
Although not recognized to occur in human cancers, mutation can also lead to increased …