[HTML][HTML] Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells
SL Heatley, G Pietra, J Lin, JML Widjaja… - Journal of Biological …, 2013 - ASBMB
Natural killer (NK) cell recognition of the nonclassical human leukocyte antigen (HLA)
molecule HLA-E is dependent on the presentation of a nonamer peptide derived from the
leader sequence of other HLA molecules to CD94-NKG2 receptors. However, human
cytomegalovirus can manipulate this central innate interaction through the provision of a"
mimic" of the HLA-encoded peptide derived from the immunomodulatory glycoprotein UL40.
Here, we analyzed UL40 sequences isolated from 32 hematopoietic stem cell …
molecule HLA-E is dependent on the presentation of a nonamer peptide derived from the
leader sequence of other HLA molecules to CD94-NKG2 receptors. However, human
cytomegalovirus can manipulate this central innate interaction through the provision of a"
mimic" of the HLA-encoded peptide derived from the immunomodulatory glycoprotein UL40.
Here, we analyzed UL40 sequences isolated from 32 hematopoietic stem cell …
