Downmodulation of CXCL8/IL-8 receptors on neutrophils after recruitment in the airways
P Pignatti, G Moscato, S Casarini, M Delmastro… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: CXCL8/IL-8 is the most significant chemokine for neutrophils, and CXC
chemokine receptor (CXCR) 1 and 2 are its 2 receptors, which are downmodulated by
CXCL8/IL-8 and endotoxin on activated neutrophils. OBJECTIVE: We sought to evaluate the
expression of the CXCL8/IL-8 receptors and the activation marker CD11b on neutrophils in
peripheral blood and in the site of airway inflammation. METHODS: The flow cytometric
expression of CXCR1, CXCR2, and CD11b was evaluated on peripheral blood and induced …
chemokine receptor (CXCR) 1 and 2 are its 2 receptors, which are downmodulated by
CXCL8/IL-8 and endotoxin on activated neutrophils. OBJECTIVE: We sought to evaluate the
expression of the CXCL8/IL-8 receptors and the activation marker CD11b on neutrophils in
peripheral blood and in the site of airway inflammation. METHODS: The flow cytometric
expression of CXCR1, CXCR2, and CD11b was evaluated on peripheral blood and induced …