PRL-3 and PRL-1 promote cell migration, invasion, and metastasis
Q Zeng, JM Dong, K Guo, J Li, HX Tan, V Koh… - Cancer research, 2003 - AACR
We demonstrate here that Chinese hamster ovary cells stably expressing PRL-3, a M r
20,000 prenylated protein tyrosine phosphatase, or its relative, PRL-1, exhibit enhanced
motility and invasive activity. A catalytically inactive PRL-3 mutant has significantly reduced
migration-promoting activity. We observe that PRL-3 is associated with diverse membrane
structures involved in cell movement. Furthermore, we show that PRL-3-and-1-expressing
cells, but not control cells, induce metastatic tumor formation in mice. Thus, our results …
20,000 prenylated protein tyrosine phosphatase, or its relative, PRL-1, exhibit enhanced
motility and invasive activity. A catalytically inactive PRL-3 mutant has significantly reduced
migration-promoting activity. We observe that PRL-3 is associated with diverse membrane
structures involved in cell movement. Furthermore, we show that PRL-3-and-1-expressing
cells, but not control cells, induce metastatic tumor formation in mice. Thus, our results …
Abstract
We demonstrate here that Chinese hamster ovary cells stably expressing PRL-3, a Mr 20,000 prenylated protein tyrosine phosphatase, or its relative, PRL-1, exhibit enhanced motility and invasive activity. A catalytically inactive PRL-3 mutant has significantly reduced migration-promoting activity. We observe that PRL-3 is associated with diverse membrane structures involved in cell movement. Furthermore, we show that PRL-3- and -1-expressing cells, but not control cells, induce metastatic tumor formation in mice. Thus, our results deliver the first evidence for a causative role of PRL-3 and -1 in promoting cell motility, invasion activity, and metastasis.
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