[HTML][HTML] Structural insights into molecular function of the metastasis-associated phosphatase PRL-3
G Kozlov, J Cheng, E Ziomek, D Banville… - Journal of biological …, 2004 - ASBMB
Phosphatases and kinases are the cellular signal transduction enzymes that control protein
phosphorylation. PRL phosphatases constitute a novel class of small (20 kDa), prenylated
phosphatases with oncogenic activity. In particular, PRL-3 is consistently overexpressed in
liver metastasis in colorectal cancer cells and represents a new therapeutic target. Here, we
present the solution structure of PRL-3, the first structure of a PRL phosphatase. The
structure places PRL phosphatases in the class of dual specificity phosphatases with closest …
phosphorylation. PRL phosphatases constitute a novel class of small (20 kDa), prenylated
phosphatases with oncogenic activity. In particular, PRL-3 is consistently overexpressed in
liver metastasis in colorectal cancer cells and represents a new therapeutic target. Here, we
present the solution structure of PRL-3, the first structure of a PRL phosphatase. The
structure places PRL phosphatases in the class of dual specificity phosphatases with closest …